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KMID : 0923620160160060366
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Immune Network
2016 Volume.16 No. 6 p.366 ~ p.372
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Interleukin 17-expressing Innate Synovial Cells Drive K/Bxn Serum-induced Arthritis
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Cho Wang-Shik
Jang Eun-Kyeong
Kim Ho-Youn
Youn Jee-Hee
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Abstract
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K/BxN serum can induce arthritis in normal mice because of abundant autoantibodies that trigger an innate inflammatory response in joints. To determine whether IL-17 is involved in the pathogenesis of serum-induced arthritis, we injected wild-type and IL-17?/? mice with K/BxN serum and evaluated them for signs of arthritis. Unlike wild-type mice, IL-17?/? mice did not show any signs of arthritis. IL-17 was produced predominantly by CD3? CD4? γδTCR? NK1.1? Sca1int Thy1hi cells residing in the inflamed synovial tissue. When synovial cells extracted from normal joints were stimulated with IL-23 or autoantibody-containing immune complexes, a substantial fraction of Sca1int Thy1hi cells produced IL-17. Thus, we have identified a novel population of IL-17-producing innate synovial cells that play a crucial role in the development of K/BxN serum-induced arthritis.
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KEYWORD
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IL-17, Synovial cells, Arthritis, Immune complex
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